A new derivative spectroscopy method was developed and validated for the determination of Dexketoprofen Tromatamol in Bulk and formulation. The method involved zero order and 1st derivative spectroscopy based on the measurement of absorbance at Zero crossing point, i.e. ZCP of Dexketoprofen Tromatamol (247.0 nm) for 1st order and (260 nm) for zero order. Beer’s law was obeyed in the concentration range between 9-24 μg/ml for Dexketoprofen Tromatamol. The results of analysis have been validated statistically and by recovery studies. The method was found to be simple, precise, reproducible, less time consuming and economical. Hence it is more suitable for routine analysis of these drugs in combined dosage forms.
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